ReMemory

Develop a Cognitive Training program (CT) for MCI based on life-logging captured by a Wearable Camera

 

Mild Cognitive Impairment (MCI)

The mild cognitive impairment (MCI) is a clinical entity characterized by difficulties in some of the cognitive functions (for example, memory) and it is considered as a risk factor to develop dementia. As it consists a period of time in which cognitive difficulties are subtle, it represents a key period for intervening and altering the course of cognitive and/or functional impairment, for example: delaying it.

 

The purpose of the project is to develop a Cognitive Training program

for people with MCI. This program is based on the recording of daily life by capturing images with a portable camera. Using these images we will create specific autobiographical episodes that will be integrated later in the treatment to stimulate the episodic memory.

 

This project

represents the first systematic clinical trial with 30 patients with DCL to evaluate the effectiveness of re-experimentation of episodes to improve memory. The objective of this intervention is ­­ the individual to re-experiment these episodes activating memory, emotions and sensations, achieving a better memory of the lived episode.

Objectives

The main goal of Re-memory is to develop a program-based on life-logging intervention strategy, we call Re-memory, specially devoted to delay the evolutiono of the disease of MCI subjects by:

Continuously acquiring individual’s periods of life (e.g. two-weeks) and recording autobiographical episodes (personal experienced events). Stimulating posteriorly the episodic memory function known to be deficient in MCI by episodes reviewing and exercising their memory.

To this purpose, Re-memory will address the following main goals:

1.

Since the use of individual resources facilitates the improvement of memory, one of the objectives is to develop a personalized cognitive stimulation program, including personal material based on the episodes of each user.

2.

To evaluate the effectiveness of the intervention program to improve the memory of patients with MCI, in addition to other cognitive functions, emotional well-being and functional capacity.

 

3.

To explore the use and applicability of biomarkers to quantify the improvement in memory due to from our intervention program.

 

Structure of the project

Collection of images

First of all, images of the daily life of the person will be collected using a portable camera for 2 weeks. This camera automatically captures a photo every 30 seconds. It does not record any video or sound. The user who takes the camera is free to decide when he wants to take photos and when not. All these photos (about 100.000 images per person) will be stored and treated with total confidentiality by automatic algorithms that select those valid images to build the episodes.

Creation of episodes

With this material, the algorithms will define and extract the significant events of each individual and will create the episodes. These episodes will be accessible to users in order to work with them. The images taken with the camera contain the events of the person wearing the camera. We apply Computer Vision and Deep Learning algorithms in order to extract the main events of the person (breakfast, taking the bus, walking with the family, having a coffee with friends…). Finally we apply summarizing algorithms to extract the richest and most representative images in order to create cognitive activities from the intervention program.

Intervention program

The intervention program will consist of these episodes, as well as a variety of interactive functions (activities with different levels, a useful guide on memory, a photo album…). Before starting the intervention program and as soon as it ends, cognitive functions, functional capacity and emotional well-being of the patient will be evaluated. Moreover, to see if the improvement is maintained over time, the same evaluation will be carried out after 3 months.

Information for participants

Who is it directed to?

The project is destined to people with mild cognitive impairment (MCI), who want to collaborate in the development of a tool (instrument) to improve memory.

What does it involve to participate?

If you decide to participate in this project, you will be asked to bring a portable camera for a few days and afterwards you will have to attend to some sessions of evaluation and treatment.

What should I do to participate?

If you are interested in participating, please contact us and we will provide you information about all the procedures.

If you have any questions you can consult the FAQ section (Frequently Asked Questions) or contact us.

The final outcome of ReMemory

A new strategy of intervention based on the life record applied especially to patients with MCI, with the objective of delaying the evolution of the disease.

A new application of human resources for the management of episodic videos (retrieval, visualization, annotation…) interacted with patients, family members and medical experts to use it in a clinical setting.

This would be the first study to evaluate the feasibility of achieving significant changes in the BDNF serum level within an intervention framework based on lifelogging technology.

A first systematic clinical trial on thirty Middle Cognitive Impairment patients to show the effects of life-logging “re-memoryzing”.

Re-Memory is especially destined to MCI, although other patients with cognitive impairment may also benefit from this cognitive training.

Early studies on the effects of lifelogging in single case studies with amnesic patients have obtained very promising results. Our team strongly believes that by developing an image processing application based on the lifelogging and cognitive training conducted in a clinical setting, elderly people (mostly) with MCI will be able to improve their own memory as well as delaying the cognitive decline.

In this way, by helping elderly people to keep good memories, Re-Memory will become a substantial tool to improve their functional capacity and emotional well-being, which is the basis for greater autonomy, and therefore, a higher quality of life.

Clinical trial

Our clinical trial is registered in www.clinicaltrials.gov

https://clinicaltrials.gov/ct2/show/study/NCT02592187#contacts

ClinicalTrials.gov Identifier: NCT02592187